Our Breakthroughs
SickKids is dedicated to advancing research to improve and save lives. Supported by our generous community of donors, including those making unrestricted gifts, here are some highlights of groundbreaking research and discoveries over the past year.
Researchers show whole genome sequencing can identify hidden changes in genomes of patients with cardiomyopathy
An international group of researchers, led by SickKids, used whole genome sequencing to uncover genetic changes associated with childhood cardiomyopathy that would not have been found by standard clinical genetic tests.
SickKids-led research uncovers potential immune-based therapy for difficult to treat childhood cancers
Immune checkpoint inhibitors may help treat some childhood cancers that are resistant to more common cancer treatments such as chemotherapy and radiation therapy.
Innovative ultrasound technique developed by SickKids and Sinai researchers enables earlier detection of placental diseases
Placental diseases are often implicated in still births and other serious illnesses of newborns, making early detection techniques critical.
Researchers uncover new leukemia cell invasion pathway into central nervous system
A route by which leukemia cells enter the central nervous system discovered by SickKids and UHN researchers offers new insights that could lead to more targeted treatment options for acute lymphoblastic leukemia.
SickKids-led research demonstrates first use of exosomes as fetal therapy using animal models and human lung cells
International research team used exosomes from amniotic fluid stem cells in animal models and human lung cells to treat underdeveloped fetal lungs, restarting growth and normal functioning.
Cracking the genetic code: SickKids researchers develop new method to classify genetic variants
Researchers are working to make the human genome easier to understand, detailing a novel genome-editing strategy using CRISPR technology to better analyze and interpret genetic variations.